Americas · United States
Hotels in Depew
Compare prices from multiple booking suppliers and find the best hotel deal in Depew.
Compare hotels in Depew
Showing 29 of 29
Pink Fountain Motor Inn
5474 Transit Rd, 14043
0.3 miles by road from the centre of Depew · 6 min walk
13 Mi to Buffalo: Cozy Apartment in Depew!
102 Main St
0.7 miles by road from the centre of Depew · 13 min walk
Depew Vacation Rental ~ 10 Mi to Buffalo!
6 Princeton Ave, 14043
1.2 miles by road from the centre of Depew · 22 min walk (1.1 miles)
Nearby towns
Hotels further out or listed under other towns near Depew, cheapest first.
TownePlace Suites Buffalo Airport
9.1259 reviews4265 Genesee Street
Nearby: Cheektowaga, 2.6 miles as the crow flies
Courtyard by Marriott Buffalo Airport
9.0532 reviews4243 Genesee Street
Nearby: Cheektowaga, 2.6 miles as the crow flies
Fairfield Inn & Suites – Buffalo Airport
9.0504 reviews4271 Genesee Street
Nearby: Cheektowaga, 2.6 miles as the crow flies
Homewood Suites by Hilton Buffalo/Airport
9.0350 reviews760 Dick Road, NY 14225
Nearby: Buffalo, 2.9 miles as the crow flies
Hilton Garden Inn Buffalo Airport
8.8450 reviews4201 Genesee Street
Nearby: Cheektowaga, 2.7 miles as the crow flies
The Delavan Hotel
8.7843 reviews6461 Transit Rd
Nearby: Bowmansville, 2.3 miles as the crow flies
Hampton Inn & Suites - Buffalo Airport
8.6492 reviews133 Buell Avenue
Nearby: Cheektowaga, 2.9 miles as the crow flies
Aloft by Marriott Buffalo Airport
8.6490 reviews4219 Genesee Street
Nearby: Cheektowaga, 2.6 miles as the crow flies
Red Roof Inn Buffalo - Niagara Airport
8.2537 reviews146 Maple Drive, 14026
Nearby: Williamsville, 3.1 miles as the crow flies
Sleep Inn & Suites Buffalo Airport
8.01,244 reviews100 Holtz Drive
Nearby: Cheektowaga, 2.6 miles as the crow flies
Buffalo Airport Hotel
8.0880 reviews4600 Genesee Street
Nearby: Cheektowaga, 2.5 miles as the crow flies
Comfort Inn & Suites Buffalo Airport
7.81,149 reviews4345 Genesee Street
Nearby: Buffalo, 2.6 miles as the crow flies
Garden Place Hotel
7.62,101 reviews6615 Transit Road, NY 14221
Nearby: Buffalo, 3 miles as the crow flies
Baymont by Wyndham Buffalo
7.6827 reviews3475 Union Rd, NY 14225
Nearby: Buffalo, 3.1 miles as the crow flies
La Quinta Inn by Wyndham Buffalo Airport
7.6795 reviews6619 Transit Rd, 14221
Nearby: Williamsville, 3 miles as the crow flies
Holiday Inn Express & Suites Buffalo Airport, NY
7.6610 reviews131 Buell Avenue, NY 14225
Nearby: Buffalo, 2.9 miles as the crow flies
Quality Inn Buffalo Airport
7.0288 reviews4217 Genesee Street
Nearby: Cheektowaga, 2.7 miles as the crow flies
Extended Stay America Suites - Buffalo - Airport
6.4536 reviews901 Dick Road, NY 14225
Nearby: Buffalo, 2.9 miles as the crow flies
Suburban Studios Buffalo Airport
5.878 reviews4217 Genesee Street Building B, NY 14225
Nearby: Buffalo, 2.7 miles as the crow flies
HomeTowne Studios by Red Roof Buffalo - Niagara Airport
5.09 reviews146 Maple Drive, Building B, Bowmansville, New York, 14026
Nearby: Bowmansville, 3 miles as the crow flies
Luxury Villa
3677 Walden Avenue
Nearby: Lancaster, 1.4 miles as the crow flies
Pet-friendly Lancaster Home 13 Mi to Dtwn Buffalo
32 Maple Ave, Lancaster, New York, 14086
Nearby: Lancaster, 1.5 miles as the crow flies
Central Apt in Cheektowaga w/ Private Deck!
232 Meadowlawn Rd
Nearby: Buffalo, 2.3 miles as the crow flies
Cozy Duplex Near BUF International Airport
10 Surfside Parkway Left Apartment, NY 14225
Nearby: Cheektowaga, 2.5 miles as the crow flies
Hospitality Inn - Buffalo Airport
6627 Transit Rd, Buffalo, New York, 14221
Nearby: Buffalo, 3.1 miles as the crow flies
Dog-friendly Home ~ 14 Mi to Highmark Stadium
3683 Genesee St, 14225
Nearby: Buffalo, 3.3 miles as the crow flies
About hotels in Depew
29 hotels listed for Depew and the towns around it, 3 of them in Depew itself, with prices compared across multiple booking platforms in real time. Across the 13 currently priced properties, the average nightly rate is around US$238, with stays from US$119 up to US$327. Most properties are 3-star (17 of 29).
Hotels
29
3 in Depew · 13 priced
Average rate
US$238
per night
Cheapest
US$119
per night
Top-rated
0
of the 3 in Depew rated 9+ / 10
0 Budget
under US$100
6 Mid
US$100–US$250
7 Luxury
over US$250
What's on in Depew
22 Nov 2026
Club Seats: Bills vs Dolphins
Highmark Stadium
Hotels →
22 Nov 2026
Miami Dolphins at Buffalo Bills
Highmark Stadium
Hotels →
Includes events within 16 miles of Depew.
Staying in Depew
Planning a stay in Depew, United States? Compare 29 hotels nearby with live prices and book close to what you came for.
Typical weather
October here averages 11°C, with around 98 mm of rain across the month.
November here averages 5°C, with around 75 mm of rain across the month.
Climate data: NASA POWER
Twenty-year averages for this area, not a forecast.
Nearby: Buffalo Niagara International Airport (BUF)
Worth visiting from Depew
Distances are in a straight line.